Ranexa is used to treat adults with angina that keeps coming back, also known as chronic angina. Learn how Ranexa can help you reach your goal of angina control. Find out what to expect while taking Ranexa and how Ranexa can help.
What is Ranexa?
Ranexa is a prescription medicine used to treat adults with angina that keeps coming back (chronic angina). Ranexa may be used with other medicines that are used for heart problems and blood pressure control.
IMPORTANT SAFETY INFORMATION
Who should not take Ranexa?
Do not take Ranexa if:
- you take any of the following medicines:
- for fungus infection: ketoconazole (Nizoral), itraconazole (Sporanox, Onmel)
- for infection: clarithromycin (Biaxin)
- for depression: nefazodone
- for HIV: nelfinavir (Viracept), ritonavir (Norvir), lopinavir and ritonavir (Kaletra), indinavir (Crixivan), saquinavir (Invirase).
- for tuberculosis (TB): rifampin (Rifadin), rifabutin (Mycobutin), rifapentine (Priftin)
- for seizures: phenobarbital, phenytoin (Phenytek, Dilantin, Dilantin‐125), carbamazepine (Tegretol)
- the herbal supplement St. John's wort
- you have scarring (cirrhosis) of your liver
What are the possible side effects of Ranexa?
- Ranexa may cause serious side effects, including
- changes in the electrical activity of your heart called QT prolongation. Your doctor may do tests to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded, or feel your heart beating irregularly or fast, as these may be symptoms of QT prolongation. Also tell your doctor if you, or a family member, have a history of a heart problem called "QT prolongation” or “long QT syndrome."
- kidney failure in people who already have severe kidney problems. Your doctor may need to do tests to check how your kidneys are working.
- The most common side effects of Ranexa include dizziness, headache, constipation and nausea.
- Tell your doctor if you have any side effect that bothers you or does not go away.
What else do I need to know about taking Ranexa?
- Tell your doctor about all medical conditions you have and about all of the medicines you take, including prescription and non‐prescription medicines, vitamins and herbal supplements. Ranexa may affect the way other medicines work and other medicines may affect how Ranexa works.
- Swallow Ranexa tablets whole. Do not crush, break, or chew Ranexa tablets.
- If you miss a dose of Ranexa, wait to take the next dose at your regular time. Do not take more than 1 dose at a time.
- Limit the amount of grapefruit products you eat or drink. Grapefruit can cause your blood levels of Ranexa to increase.
- Ranexa can cause dizziness, lightheadedness, or fainting. If you have these symptoms, do not drive a car, use machinery, or do anything that needs you to be alert.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1‐800‐FDA‐1088.
Please see full Prescribing Information including Patient Information for Ranexa (ranolazine).