About Ranexa

What is Ranexa?

Ranexa is a prescription medicine used to treat adults with angina that keeps coming back (chronic angina). Ranexa may be used with other medicines that are used for heart problems and blood pressure control.

Please see Important Safety Information about Ranexa.

What is chronic angina?

Chronic angina means pain or discomfort that keeps coming back in any of these areas1:


There are other possible signs and symptoms of angina including shortness of breath.

Angina usually comes on when you are active or under stress. Chronic angina is a symptom of a heart problem called coronary heart disease (CHD), also known as coronary artery disease (CAD). When you have CHD, the blood vessels in your heart become stiff and narrow. Oxygen-rich blood cannot reach your heart muscle easily. Angina comes on when too little oxygen reaches your heart muscle.

What you might expect with Ranexa

The CARISA study was a 12-week clinical trial of about 800 patients with chronic angina. About a third of the patients took Ranexa (ranolazine) 1000 mg and their regular angina medicines. Another group of patients took their regular medicines without Ranexa. The average age of patients in the study was 64 years old. Over 75% of them were men.

The study showed that, compared to patients taking their regular angina medicines without Ranexa, patients taking Ranexa had2:

Not all patients respond to Ranexa the same way. Men improved more than women in exercise time and in lowering the number of angina attacks per week. In the CARISA study, the most common side effects reported were constipation, dizziness, nausea, and weakness.


Who should not take Ranexa?

Do not take Ranexa if:

See below for additional Important Safety Information.

Learn more about Ranexa:


What are the possible side effects of Ranexa?

What else do I need to know about taking Ranexa?

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1‐800‐FDA‐1088.

Please see full Prescribing Information including Patient Information for Ranexa (ranolazine).


  1. Ranexa [patient information]. Foster City, CA: Gilead Sciences, Inc.; 2013.
  2. Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004;291:309-316.