Staying on course with Ranexa
Angina is a chronic condition that needs to be managed over time
Chronic angina is angina that keeps coming back. Learning as much as you can about your chronic angina may help you feel more in control. When you understand your angina, you have taken the first step toward staying on course with your treatment and your cardiologist's instructions.
Angina may be a symptom of a heart problem called coronary heart disease (CHD), also known as coronary artery disease (CAD). People with angina can have pain or discomfort in the chest, jaw, shoulder, back, neck, or arm. They can have other signs and symptoms of angina, including shortness of breath. Angina usually comes on when you are active or under stress.
How to take Ranexa
Ranexa is available by prescription only.
- Take Ranexa exactly as your doctor tells you.
- Your doctor will tell you how much Ranexa to take and when to take it.
- Do not change your dose unless your doctor tells you to.
- Tell your doctor if you still have symptoms of angina after starting Ranexa.
- Take Ranexa by mouth, with or without food.
- Swallow the Ranexa tablets whole. Do not crush, break, or chew Ranexa tablets before swallowing.
- If you miss a dose of Ranexa, wait to take the next dose of Ranexa at your regular time. Do not make up for the missed dose. Do not take more than 1 dose at a time.
- If you take too much Ranexa, call your doctor, or go to the nearest emergency room right away.
IMPORTANT SAFETY INFORMATION
What are the possible side effects of Ranexa?
- Ranexa may cause serious side effects, including
- changes in the electrical activity of your heart called QT prolongation.
Your doctor may do tests to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded,
or feel your heart beating irregularly or fast, as these may be symptoms of QT prolongation. Also tell your doctor if you, or a
family member, have a history of a heart problem called "QT prolongation” or “long QT syndrome."
- kidney failure in people who already have severe kidney problems. Your doctor may need to do tests to check how your kidneys are working.
- The most common side effects of Ranexa include dizziness, headache, constipation, and nausea.
- Tell your doctor if you have any side effect that bothers you or does not go away.
Who should not take Ranexa?
Do not take Ranexa if:
- you take any of the following medicines:
- for fungus infection: ketoconazole (Nizoral), itraconazole (Sporanox, Onmel)
- for infection: clarithromycin (Biaxin)
- for depression: nefazodone
- for HIV: nelfinavir (Viracept), ritonavir (Norvir), lopinavir and ritonavir (Kaletra), indinavir (Crixivan), saquinavir (Invirase)
- for tuberculosis (TB): rifampin (Rifadin), rifabutin (Mycobutin), rifapentine (Priftin)
- for seizures: phenobarbital, phenytoin (Phenytek, Dilantin, Dilantin‐125), carbamazepine (Tegretol)
- the herbal supplement St. John's wort
- you have scarring (cirrhosis) of your liver
What else do I need to know about taking Ranexa?
- Tell your doctor about all medical conditions you have and about all of the medicines you take, including prescription and non‐prescription medicines, vitamins, and herbal supplements. Ranexa may affect the way other medicines work and other medicines may affect how Ranexa works.
- Swallow Ranexa tablets whole. Do not crush, break, or chew Ranexa tablets.
- If you miss a dose of Ranexa, wait to take the next dose at your regular time. Do not take more than 1 dose at a time.
- Limit the amount of grapefruit products you eat or drink. Grapefruit can cause your blood levels of Ranexa to increase.
- Ranexa can cause dizziness, lightheadedness, or fainting. If you have these symptoms, do not drive a car, use machinery, or do anything that needs you to be alert.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1‐800‐FDA‐1088.
Please see full Prescribing Information including Patient Information for Ranexa (ranolazine).