Ranexa (ranolazine extended-release tablets) for the treatment of chronic angina does not depend upon reductions in heart rate or blood pressure http://www.ranexa.com/wir_indications.html
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Ranexa.com References
 

Ranexa.com References

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  1. Ranexa® (ranolazine extended-release tablets). [Prescribing Information]. CV Therapeutics, Inc; December 2007.
  2. Data on file. RAN00230-2. CV Therapeutics, Inc.
  3. Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial. JAMA. 2004;291:309-16.
  4. Stone PH, Gratsiansky NA, Blokhin A, Huang IZ, Meng L; ERICA Investigators. Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. 2006;48(3):566-75. Epub 2006 Jun 15.
  5. Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina: A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for the Management of Patients with Chronic Stable Angina). 2002. Available at http://www.acc.org/qualityandscience/clinical/guidelines/stable/
    stable_clean.pdf
    . Accessed September 6, 2006.
  6. Braunwald E. The history. In: Zipes DP, Libby P, Bonow RO, and Braunwald E, eds. Braunwald’s Heart Disease – A Textbook of Cardiovascular Medicine. 7th edition. Philadelphia, Penn: Elsevier Saunders; 2005:63-77.
  7. Kern MJ. Atherosclerotic cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, and Braunwald E, eds. Braunwald’s Heart Disease – A Textbook of Cardiovascular Medicine. 7th edition. Philadelphia, Penn: Elsevier Saunders; 2005:1103-27.
  8. Van Herck PL, Vrints CJ, Carlier SG. Coronary circulation and interventional cardiology. Ann Biomed Eng. 2005;33:1735-42.
  9. Kloner RA, Jennings RB. Consequences of brief ischemia: Stunning, preconditioning, and their clinical implications: Part 1.
    Circulation.
    2001;104:2981-9.
  10. Cohn PF, Fox KM, Daly C. Silent myocardial ischemia. Circulation. 2003;108:1263-77.
  11. American Heart Association. Heart Disease and Stroke Statistics — 2007 Update. Dallas, Texas: American Heart Association; 2007.
  12. Daly CA, De Stavola BE, Lopez Sendon JL, Tavazzi L, Boersma E, Clemens F, et al. Predicting prognosis in stable angina – Results from the Euro Heart Survey of stable angina: Prospective observational study. BMJ. 2006:332:262-7.
  13. Poole-Wilson PA, Jacques A, Lyon A. Treatment of angina: A commentary on new therapeutic approaches. Eur Heart J. 2005;8(Suppl):A20-25.
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